Sara Pezzini,
is a NYPD-cop who is blessed, or cursed, with the Witchblade.
Read more on her.

Kenneth Irons,
a billionaire businessman and criminal mastermind who is opsessed with the Witchblade.
Read more on him.

Ian Nottingham,
a assasin who is the only man who ever used the Witchblade.
Read more on him.

Jake McCarthy,
a homicide detective who is asigned to be Sara's partner.
Read more on him.

Joe Siry,
is Sara's police chief.
Read more on him.

Setsuke,
is considered the daughter of Ian Nottingham.
Read more on her.